Hi KLH. As you know, prednisone is the Med everyone loves to hate. I just don't believe we have been fully explained how it works. It is supposed to reduce inflammation and keep the Body from attacking itself. The body looks at our own Lung damage as an Enemy. What A Shame!
Predz work by tamping down the body's defense mechanisms. Like pulling in the reigns of a team of Clydesdales. Or stepping on the brakes if a trigger-tuned dragster! (My favorite 🏁) Whoa indeed!
Anyway, I take a low dose every day. It's like a Tic-tac most days. When I have to do a "booster dosage", I never take the whole dose at one time. Nor along with any other meds. Or at night.

It only takes about 4 hours for one-half of the Preds to dispense through the body. It helps to take it in the AM after a meal or at least a glass of milk. Or juice (not grapefruit). And extra water (fluids) all day helps too. You can't see the goop it is breaking up in the lungs and tissues but the extra water helps flush it away. By the time the next dose is due, a majority of the previous dose is gone. We start this process all over again.

Here is the best article I could find that describes the process with regard to giving Predz the highest priority in your medicine schedule. Hope this helps some:
https://hellopharmacist.com/questions/how-long-...
Hoping you feel better after this Go-round.