check into sleep apnea / the occurrence is higher for those of us with diminished breathing capacity and lower oxygen levels .cause tiredness and restless leg syndrome

I am also on Salbutamol and Spiriva but never thought they were connected. I was on them for a long time. Then a year later the Shakey Leg Syndrome started. I think it's one of the new drugs I'm taking. (Barb)

Sounds like you have "Shakey Leg Syndrome" like I do. I'm on 2 Parkinson Pills at night when I go to bed. Work wonderful! I'm Able to sleep right through the night. The actual drug is called Act-Pramipexole 0.25 mg. Hope this answers your question.

I think it's the side effect of meds we take for COPD. I have the same problem but not in the extreme. I'd check with Doctor, you are having an extreme reaction to one of your meds.

I would either look up side affects of your medicine, or ask your doctor or pharmacist if your medicine could cause this. A friend of mine shook so bad they could not feed themselves. Turned out to be some medicine they were taking.