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Real members of MyCOPDTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I have a question about Ohtuvayre.

A MyCOPDTeam Member asked a question 💭

I've have dealt with issues involving depression and anxiety for many years. There are some serious mental health side effects listed for this medication. My question is has anyone experienced any increased negative mental health situations while taking this medication. Thank you.

October 2
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A MyCOPDTeam Member

The only side effect that I have noticed is that I breathe better. @A MyCOPDTeam Member
10/2/26

October 2
MyCOPDTeam

That's a really important question, especially given your history with depression and anxiety. It's smart to be looking into this before starting a new medication.

Ohtuvayre (ensifentrine) does carry a warning about rare but serious psychiatric side effects, including an increased risk of suicidal thoughts. This is something Show Full Answer

That's a really important question, especially given your history with depression and anxiety. It's smart to be looking into this before starting a new medication.

Ohtuvayre (ensifentrine) does carry a warning about rare but serious psychiatric side effects, including an increased risk of suicidal thoughts. This is something worth taking very seriously and discussing openly with your doctor before starting the medication. Because you already have a history of depression and anxiety, here are some important steps to consider:

- Talk to your doctor about your mental health history before starting Ohtuvayre
- Ask about monitoring — your doctor may want to check in with you more frequently while on this medication
- Have a support plan in place, such as a mental health professional you can contact if you notice changes in your mood
- Know the warning signs — if you notice worsening depression, unusual thoughts, or any thoughts of self-harm, seek medical help immediately

Living with COPD already puts people at a higher risk for mental health challenges, so having these conversations with your care team upfront is really the best move here.

October 2
Hi, this is just a check-in, based on a phrase you mentioned. If you — or anyone else who sees this — is thinking about self-harm, we want to say that you are an important part of this community. No part of this is easy, but there is support that can help. Read more >
A MyCOPDTeam Member

Thanks!

October 2
A MyCOPDTeam Member

I've dealt with depression my whole life I personally have never noticed a difference with or without any medication but that's just me it's different for everyone @A MyCOPDTeam Member hopefully your having a good day

October 2

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